Malignant Lymphoma

Genitourinary malignant lymphomas are uncommon, representing less than 7% of all extranodal lymphomas.39 The majority of cases are secondary to systemic dissemination and the most frequently affected anatomical site is the testicle. Primary penile lymphomas are exceedingly rare.122 Non-Hodgkin lymphomas, either of B or T cell types, predominate over Hodgkin lymphomas. Histologically, a dense infiltrate of atypical lymphocytes is seen (Fig. 3.19d). Despite the rarity of the lesion, establishing a suspicion of a penile lymphoma should be straightforward. Confirmation and phenotyping is done by immunohistochemistry following the criteria established for lymphomas elsewhere. In the very rare cases of mycosis fungoides of the penis, neoplastic cells can be confused with extramammary Paget's disease.93

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