Penile Cancer Imaging

As regards neoplasms of the penis, it has been demonstrated that lymphotropic nano-particle-enhanced magnetic resonance imaging (LNMRI) with ferumoxtran-10 can accurately predict the pathological status of regional lymph nodes.33,34 Ferumoxtran-10 is made up of superparamagnetic iron oxide nanoparticles, which are phagocytosed by macrophages in normal lymph nodes and these show homogeneous uptake of ferumoxtran-10 and appear dark on T2-weighted MR images. However, lymph nodes containing metastases lack these macrophages and subsequently do not accumulate the nanoparticles and appear bright on T2 imaging. Using this technique it is possible to detect subcentimeter metastases in morphologically normal lymph nodes and also to accurately differentiate malignancy from enlarged reactive lymph nodes. In seven patients with penile cancer, MRI with lymphotrophic nanoparticles was 100% sensitive and 97% specific for lymph node metastasis.33

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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