Perineural Invasion

Perineural invasion is defined by the presence of tumoral nests composed of poorly differentiated neoplastic cells in the perineural space. Recently, Chaux et al. highlighted that perineural invasion was an independent predictor of pathological lymph node involvement together with histological grades. As a result of this observation, the presence/absence of perineural invasion was included in a prognostic index designed to predict the presence of nodal metastases in patients with penile cancer. Perineural invasion was not shown to be an independent predictor of cancer-specific survival.33 Although this parameter should be taken into consideration by patholo-gists and reported in the final histopathological evaluation, its prognostic role needs to be elucidated in further studies.

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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