Squamous Cell Carcinoma Antigen SCC Antigen

SCC antigen (TA-4) is a 43 kDa glycoprotein which has been utilized in the diagnosis and management of SCC in various tissues as a result of its release into the serum. A few studies have investigated its role in penile cancer. Wishnow et al.66 studied serum levels of SCC antigen in 23 men with carcinoma of the penis and observed that levels correlated with disease progression and were increased in those patients with metastatic disease. Laniado et al.67 investigated 11 men - seven had histological evidence of nodal disease. The sensitivity of raised serum SCC antigen in detecting nodal disease was 57% and the specificity was 100%. Touloupidis et al.68

sequentially measured SCC antigen in 16 men with penile cancer. This study once again demonstrated a possible role for SCC antigen in detecting nodal disease and response to treatment. The largest study has been performed by Hungerhuber et al.69 and consisted of 54 patients with penile cancer. SCC antigen levels correlated with tumor burden, increased significantly with extensive lymph node involvement or metastatic disease but did not predict microscopic nodal involvement. Currently, the role of SCC antigen as a prognostic marker is still limited. However, it may be used as an adjunct to sentinel lymph node biopsy in patients placed on surveillance or as a marker for disease response following chemotherapy.

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