There has been very little research looking at telomerase activity in penile cancer.50,51 Telomerase is an enzyme that adds specific DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. The telomeres contain condensed DNA material, conferring stability to the chromosomes. The enzyme is a reverse transcriptase that carries its own RNA, which is used as a template when it elongates telomeres. Telomeres are normally shortened after each replication cycle and telomerase provides a compensatory mechanism. In cancer, increased telomerase activity could possibly overcome programmed cell death, immortalizing the cell and leading to indefinite replication capacity. This mechanism might be linked to an increased probability of developing chromosomal changes and aneuploid populations. Alves and coworkers50 describe detectable telomerase activity in 85-100% of penile carcinoma, but also in adjacent noncancerous skin and corpus cavernosum. Further studies are necessary to evaluate the relevance of these findings.

Dealing With Erectile Dysfunction

Dealing With Erectile Dysfunction

Whether you call it erectile dysfunction, ED, impotence, or any number of slang terms, erection problems are something many men have to face during the course of their lifetimes.

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