Absolute Contraindications

History of thromboembolic disease

History of stroke (or current cerebrovascular disease)

History of (or current) coronary artery disease

History of carcinoma of the breast (known or suspected)

History of any estrogen-dependent neoplasm

Undiagnosed abnormal uterine bleeding

Pregnancy (known or suspected)

Heavy smokers (15 cigarettes or more per day) who are greater than 35 years of age

History of hepatic tumors (benign or malignant) Active liver disease

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