Acid Base Disturbances

Acid-base disturbances associated with PN usually are related to the patient's underlying condition(s). However, acid-base abnormalities may develop as a result of changes in chloride or acetate concentrations in PN admixtures. Because acetate is converted to bicarbonate in the body, excessive acetate salts in PN can lead to metabolic alkalosis; excessive chloride salts in PN can lead to metabolic acidosis. PN should not be used to treat or correct acute underlying disorders. However, adjusting chloride or acetate salts in the PN admixture may help to prevent these acid-base disorders or minimize worsening of any underlying acid-base disorders.

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