Allorecognition

oe Recognition of the antigens displayed by the transplanted organ (alloanti-gens) is the prime event that initiates the immune response against the allograft. There are currently two accepted pathways for T-cell allorecognition, direct and indirect pathways:

• Direct pathway: donor APCs migrate out of the allograft into the recipient's lymph nodes and present donor MHC molecules to the TCR of the recipient's T cells.

• Indirect pathway: recipient APCs migrate into the graft and phagocytize alloanti-gens. The donor MHC molecules are then expressed on the cell surface of the recipient's APCs and presented to recipient T cells in the lymph nodes.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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