Allorecognition

oe Recognition of the antigens displayed by the transplanted organ (alloanti-gens) is the prime event that initiates the immune response against the allograft. There are currently two accepted pathways for T-cell allorecognition, direct and indirect pathways:

• Direct pathway: donor APCs migrate out of the allograft into the recipient's lymph nodes and present donor MHC molecules to the TCR of the recipient's T cells.

• Indirect pathway: recipient APCs migrate into the graft and phagocytize alloanti-gens. The donor MHC molecules are then expressed on the cell surface of the recipient's APCs and presented to recipient T cells in the lymph nodes.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

Are Constant Headaches Making Your Life Stressful? Discover Proven Methods For Eliminating Even The Most Powerful Of Headaches, It’s Easier Than You Think… Stop Chronic Migraine Pain and Tension Headaches From Destroying Your Life… Proven steps anyone can take to overcome even the worst chronic head pain…

Get My Free Audio Book


Post a comment