All the anthracyclines contain a four-membered anthracene ring, a chromophore, with an attached sugar portion. Free radicals formed from the anthracyclines combine with oxygen to form superoxide, which can make hydrogen peroxide. Oxygen-free-radical formation is a cause of cardiac damage and extravasation injury, which is common to these drugs. Daunorubicin, doxorubicin, epirubicin, and idarubicin cause cardiac toxicity, as manifested by a congestive heart failure/cardiomyopathy symptomotology, mucositis, and myelosuppression. These drugs are vesicants; significant tissue damage may occur with extravasation.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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