Whether due to their antihistaminic activity or their sedative side effects, pruritus caused by contact dermatitis can be relieved with the use of sedating oral antihistam-ines such as diphenhydramine or hydroxyzine. Topical antihistamines are available, but use is limited due to their high-sensitizing potential.26,33

In addition to sedation, many oral antihistamines can cause hypotension, dizziness,

blurred vision, and confusion.

Diphenhydramine and hydroxyzine can be safely administered to children older than 2 years and adults. Table 65-7 outlines the recommended doses for these medications.

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