Antihyperuricemic Therapy

• Assess for new gouty arthritis attacks or the development of tophi. If neither one develops, continue antihyperuricemic therapy as prescribed.

• Obtain the first follow-up SUA level within 6 months of starting therapy. Then monitor levels at least every 6 to 12 months, and adjust the dose to achieve a target SUA level of less than 6 mg/dL (357 ^mol/L).

• Evaluate patients taking allopurinol for development of rash, nausea, or new fever. These symptoms usually appear within the first 3 months of therapy but can occur anytime.

• Assess patients receiving probenecid for fever, nausea, or skin rash. Reevaluate therapy if a significant decrease in urine output occurs (greater than 50% in a 24-hour period).

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