Application of Ophthalmic Solutions or Suspensions

1. Clean hands with soap and water.

2. Avoid touching the dropper tip with your fingers or against your eye to maintain sterility of product; shake dropper bottle if product is a suspension.

3. Tilt head back; pull down the lower eye lid with index finger.

4. Hold the dropper bottle with other hand as close as possible without touching the eye. The dropper should be pointing toward the eye with remaining fingers bracing against the face.

5. Gently squeeze the bottle so that one drop is placed into the pocket.

6. Close your eye for 2 to 3 minutes to allow for the maximum corneal penetration of drug

7. Use a tissue to wipe away any excess liquid.

8. Replace and retighten the cap to the dropper bottle.

9. Wait at least 5 minutes before instilling another ophthalmic drug preparation

10. Application of some ophthalmic preparations (suspension and gels) may cause blurring of vision.

Adjust therapy if patients fail to reach their target IOP. Patients who have achieved target IOP yet have progressive damage of the optic nerve or who have worsening of their visual fields should have further adjustment of their therapy. Evaluate these patients further for possible reasons of continued disease progression. Consider determining the diurnal pattern of IOP and looking for signs of poor ocular perfusion pressure. Establish a lower target IOP. Adjust therapy in patients who are intolerant, nonadherent, or develop contraindications to their drug therapy regimen. Consider increasing the target IOP and reducing drug therapy for patients who have stable disease and who have maintained a low IOP; closely follow these patients to assess their 1,32

response.

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