Busulfan is an alkylating agent that forms DNA-DNA and DNA-protein cross-links to inhibit DNA replication. Oral busulfan is well absorbed, has a terminal half-life of 2 to 2.5 hours, and is eliminated primarily by metabolism. Busulfan has shown significant clinical activity in the treatment of acute myelogenous leukemia and chronic myelo-cytic leukemia. Side effects include bone marrow suppression, hyperpigmentation of skin creases, and rarely, pulmonary fibrosis. High doses used for bone marrow transplant preparatory regimens result in severe nausea and vomiting, tonic-clonic seizures, and sinusoidal obstruction syndrome (formerly known as veno-occlusive disease). Patients receiving high-dose busulfan should receive anticonvulsant prophylaxis.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

Are Constant Headaches Making Your Life Stressful? Discover Proven Methods For Eliminating Even The Most Powerful Of Headaches, It’s Easier Than You Think… Stop Chronic Migraine Pain and Tension Headaches From Destroying Your Life… Proven steps anyone can take to overcome even the worst chronic head pain…

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