Cholera Epidemiology

Cholera, the first reportable disease, is endemic in South Asia, particularly in the Ganges delta region. 2 The biotypes of Vibrio cholerae responsible for pandemics are serogroup O1 (El Tor) and serogroup O139.13,14 Although not associated with pandemics, serogroups O75 and O141 have caused small outbreaks of severe diarrhea in the United States. Cholera can be transmitted by water or by food contaminated with contaminated water, particularly undercooked seafood. V. cholerae grows well in

warm temperatures, causing marked seasonality in the incidence of cholera.

People of blood type O are more susceptible to El For vibrios than people of other blood types.15 Inoculum size affects the likelihood and severity of cholera infection. The infectious dose is lower in patients who are taking antacids owing to the neutralization of gastric acid.16

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