Clinical Presentation and Diagnosis of Acute Aplastic Crisis in SCD General

• Transient suppression of RBC production in response to bacterial or viral infection

• Most commonly due to infection with parvovirus B19 Symptoms

• Patients may complain of headache, fatigue, dyspnea, pallor, or fever

• Patients may also complain of upper respiratory or GI infection symptoms Signs

• Temperature greater than 38.5°C (101.3°F) may occur

• Tachycardia

• Acute decrease in Hgb with decreased reticulocyte count Laboratory Tests

• CBC with reticulocyte

• Parvovirus titers

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