Clinical Presentation and Diagnosis of Extravasation General

• Anthracycline, mechlorethamine, and vinca alkaloid extravasations typically cause immediate pain

• Patients may be asymptomatic at the time of extravasation, but return within days to weeks with signs of tissue damage (particularly with mitomycin C)

• Exposure to UV light may worsen some lesions Signs and Symptoms

• Local pain (burning, tingling, stinging), swelling, erythema, induration

• Lack of blood return

• Ulceration may not develop until after 1 to 2 weeks or longer

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