Clinical Presentation and Diagnosis of Infection in SCD General

• Patients may become acutely distressed very rapidly

• A low threshold to begin empiric therapy is recommended Symptoms

• Patients may complain of lethargy, nausea, cough, or a general "unwell" feeling Signs

• Temperature greater than 38.5°C (101.3°F) Laboratory Tests

• CBC with reticulocyte count

• Lumbar puncture if toxic-looking or signs of meningitis

• Urinalysis

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