Clinical Presentation and Diagnosis of SCD General

• Indentified by neonatal screening before 2 months of age Symptoms

• Painful vasoocclusive crises are the hallmark of SCD

• Dactylitis (hand-foot syndrome) before age 1 year

• May develop infarction of the spleen, liver, bone marrow, kidney, brain, and lungs

• Gallstones

• Priapism in males

• Slow healing lower extremity ulcers after trauma or infection

• Weakness, fatigue Signs

• Chronic hemolytic anemia is common

• Enlargement of spleen, and heart

• Scleral icterus Laboratory Tests

• Hgb 7 to 10 g/dL (70-100 g/L or 4.3-6.2 mmol/L)

• Low HgF and increased reticulocytes, platelets, and WBCs

• Presence of sickled cells on blood smear (see Fig. 68-2)

• Neonatal screening: hemoglobin electrophoresis, isoelectric focusing, or DNA analysis

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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