Clinical Presentation and Diagnosis of TLS General

• Patients present primarily with lab abnormalities

• Normal uric acid is equal to 2 to 8 mg/dL (119-476 |imol/L)

• Most often occurs within 12 to 72 hours of initiation of cytotoxic therapy Signs and Symptoms

• Most patients are asymptomatic

• Patients may develop edema, fluid overload, and oliguria, which may progress to anuria with acute renal failure

• Some patients with hyperuricemia may have nausea, vomiting, and lethargy

• Hyperkalemia—lethargy, muscle weakness, paresthesia, ECG changes, bradycar-dia

• Hypocalcemia—muscle cramps, tetany, irritability, paresthesias, arrhythmias Laboratory Tests (Adults)

• Serum uric acid level greater than 8 mg/dL (476 |imol/L)

• Serum potassium greater than 6 mEq/L (6 mmol/L)

• Serum phosphorus greater than 4.5 mg/dL (1.45 mmol/L)

• Elevated BUN and creatinine once renal dysfunction develops OR

• A change of greater than 25% from baseline in the above lab values

Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook


Post a comment