Clinical presentation and diagnosis Pharmacologic Therapy

The drugs used for T. cruzi include nifurtimox (Lampit) and benznidazole (Rochagan).

Oral nifurtimox is available from the CDC, while benznidazole is only available in 12 80 83

Brazil. ' OJ The adult dose of nifurtimox is 8 to 10 mg/kg/day in divided doses for 120 days. Since children seem to tolerate the dose better than adults, the pediatric dose of nifurtimox in children 1- to 10-year-old is 15 to 20 mg/kg/day, and the dose for children 11- to 16-year-old is 12.5 to 15 mg/kg/day in divided doses. Symptomatic treatment for heart failure associated with Chagas' disease should be initiated. The GI complications may require surgical revisions and reconstruction.

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