Combination Therapy

A large proportion of the U.S. population won't achieve their NCEP cholesterol targets for a variety of reasons.44 These include inadequate patient adherence, adverse events, inadequate starting doses, lack of dose escalation, and lower treatment tar-gets.3,45 Moreover, patients with concomitant elevations in triglycerides and/or low levels of HDL cholesterol may need combination drug therapy to normalize their lipid profile. Combination drug therapy is an effective means to achieve greater reductions in LDL cholesterol (statin + ezetimibe or bile acid resin, bile acid resin + eze-timibe, or three-drug combinations) as well as raising HDL cholesterol and lowering serum triglycerides (statin + niacin or fibrate).

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