Conclusion

Antimicrobial regimen selection is a complex process involving the integration of a multitude of factors. The guiding principles to make the diagnosis and do no harm must be considered when choosing an antimicrobial for a given patient. In summary, when infection is suspected, rapid and accurate diagnosis should be followed by early intervention that includes admi nistration of appropriately dosed antibiotics with appropriate empirical spectrums. De-escalation to suitable narrow-spectrum antibiotics if susceptibilities are known should occur as soon as possible, and therapy should be stopped as soon as the patient is cured. These fundamental actions improve infectious disease outcomes and minimize collateral damage and adverse effects.

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