Aminoglycosides may be administered by traditional methods (1.5-2 mg/kg every 8 hours) or by an extended dosing interval method (4-7 mg/kg every 24 hours). The extended dosing method maximizes the pharmacodynamic properties of aminoglyc-osides (concentration-dependent killing and postantibiotic effect) and reduces the incidence of nephrotoxicity. Extended dosing interval aminoglycosides have prolonged drug-free periods, during which the saturable uptake of aminoglycosides into the proximal renal tubular cells can be completed. Extended dosing interval aminoglycosides should not be used in pediatric patients, burn victims, pregnant patients, patients with pre-existing or progressive renal insufficiency, or for synergy with gram-positive or-


Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

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