Aminoglycosides may be administered by traditional methods (1.5-2 mg/kg every 8 hours) or by an extended dosing interval method (4-7 mg/kg every 24 hours). The extended dosing method maximizes the pharmacodynamic properties of aminoglyc-osides (concentration-dependent killing and postantibiotic effect) and reduces the incidence of nephrotoxicity. Extended dosing interval aminoglycosides have prolonged drug-free periods, during which the saturable uptake of aminoglycosides into the proximal renal tubular cells can be completed. Extended dosing interval aminoglycosides should not be used in pediatric patients, burn victims, pregnant patients, patients with pre-existing or progressive renal insufficiency, or for synergy with gram-positive or-


How To Bolster Your Immune System

How To Bolster Your Immune System

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