Dasatinib is a second generation tyrosine kinase inhibitor that shares the same binding site on the BCR:ABL cluster region as imatinib, but maintains activity despite imatinib resistance, with more higher potency than imatinib. Dasatinib also inhibits SRC kinases, which are tyrosine kinases that mediate cellular differentiation, proliferation and survival. The terminal half-life of dasatinib is 3 to 5 hours, with elimination primarily via the liver and feces. Dasatinib is used in the treatment of chronic myeloid leukemia with resistance or intolerance to imatinib, and for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Side effects of dasatinib include myelosuppression, nausea and vomiting, headache, fluid retention, hypocal-cemia and pleural effusions.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

Are Constant Headaches Making Your Life Stressful? Discover Proven Methods For Eliminating Even The Most Powerful Of Headaches, It’s Easier Than You Think… Stop Chronic Migraine Pain and Tension Headaches From Destroying Your Life… Proven steps anyone can take to overcome even the worst chronic head pain…

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