Dasatinib is a second generation tyrosine kinase inhibitor that shares the same binding site on the BCR:ABL cluster region as imatinib, but maintains activity despite imatinib resistance, with more higher potency than imatinib. Dasatinib also inhibits SRC kinases, which are tyrosine kinases that mediate cellular differentiation, proliferation and survival. The terminal half-life of dasatinib is 3 to 5 hours, with elimination primarily via the liver and feces. Dasatinib is used in the treatment of chronic myeloid leukemia with resistance or intolerance to imatinib, and for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Side effects of dasatinib include myelosuppression, nausea and vomiting, headache, fluid retention, hypocal-cemia and pleural effusions.

Headache Happiness

Headache Happiness

Headache Happiness! Stop Your Headache BEFORE IT STARTS. How To Get Rid Of Your Headache BEFORE It Starts! The pain can be AGONIZING Headaches can stop you from doing all the things you love. Seeing friends, playing with the kids... even trying to watch your favorite television shows. And just think of how unwelcome headaches are while you're trying to work.

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