Dextrose A

Dextrose (D-glucose) is the major immediate energy source, and it is vital for cellular metabolism, body protein preservation, and cellular growth. Several body tissues depend primarily on dextrose for energy, including the central nervous system (CNS), red blood cells, and the renal medulla.

Parenteral dextrose (hydrous dextrose) used in PN compounding typically is provided as a 70% stock solution (70 g/100 mL), although some institutions use a 50% stock solution. The final dextrose concentration in the central PN solution typically should not exceed 35%. Hydrous dextrose provides 3.4 kcal/g (14.2 kJ/g). A dextrose infusion rate of 2 mg/kg/min in adult patients is sufficient to suppress gluco-neogenesis and spare body proteins from being used for energy.4 Continuous dextrose infusion rate in hospitalized adult patients generally should not exceed 4 to 5 mg/kg/ min.5,6

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