Several laboratory tests are available to aid in the diagnosis of gonorrhea and include gram-stained smears, culture, or the DNA hybridization probe. A gram stain of a male urethral specimen that demonstrates polymorphonuclear leukocytes with intracellular gram-negative diplococci may be considered diagnostic in symptomatic men. A gramnegative stain should not be considered sufficient for ruling out infection in asymptomatic men.4 All patients who test positive for gonorrhea should be tested for other STIs, including chlamydia, syphilis, and HIV.

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