Disseminated intravascular coagulation Etiology and Epidemiology

Disseminated intravascular coagulation (DIC) is a systemic thrombohemorrhagic disorder characterized by an increased propensity for clot formation secondary to a wide variety of clinical conditions (Table 67-8). Central to the etiology of DIC is excessive and unregulated generation of thrombin, leading to an aggressive compensatory fibrinolysis. Therefore, clinical manifestations of DIC result from a loss of balance between the clot-promoting (leading to thrombosis) and the clot-lysing (leading to hemorrhage) systems. Although this balance may tip in either direction, presenting as bleeding or clotting, bleeding is most common. Incidence of bleeding, end-organ dysfunction, and other manifestations depends on the etiology of DIC.2

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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