Disseminated Intravascular Coagulation

Disseminated intravascular coagulation (DIC) complicates 25% to 50% of septic patients, and is an independent predictor of mortality.1 DIC is a syndrome characterized by coagulation and activation and production of proinflammatory cytokines, culminating in intravascular fibrin formation and deposition in the microvasculature. Bleeding results from consumption and exhaustion of coagulation proteins and platelets,

because of continued activation of the coagulation system. DIC may produce ARF, hemorrhagic necrosis of the GI mucosa, liver failure, acute pancreatitis, ARDS, and

pulmonary failure.

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