Drug Desensitization

Drug desensitization may be undertaken for some drugs in the absence of useful alternative medications. The risk of severe systemic reactions and anaphylaxis associated with desensitization must be compared to the risk of not treating the patient. Thorough evaluation should establish that the drug probably caused the reaction by an allergic mechanism. Because of the dangers involved with drug desensitization, an expert review of the patient's indication for the drug should be conducted. Consider the possibility that the patient does not really need the drug.

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