• Myalgia or arthralgias Signs

• Fever is the most common sign of IE

• New or changing heart murmur

• Embolic phenomena (emboli affect the heart, lungs, abdomen, or extremities)

• Skin manifestations (e.g., petechiae, splinter hemorrhages, Osler's nodes, Janeway's lesions)

• Splenomegaly

• Clubbing of extremities Laboratory Tests

• Blood cultures are the most important laboratory assessment for persistent bacteremia, which occurs commonly in IE. A minimum of three blood culture sets should be collected during the initial 24 hours

• Hematologic tests for anemia (normochromic, normocytic)

• WBC count may be elevated in acute disease but could be normal in subacute IE

• Nonspecific findings such as thrombocytopenia, elevated erythrocyte sedimentation rate or C-reactive protein, and abnormal urinalysis (i.e., proteinuria or microscopic hematuria)

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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