Empirical Therapy

The overall goal of therapy is to eradicate the infection and minimize/prevent any complications. Patients with suspected IE should be evaluated for risk factors that may provide some indication as to the most likely organism causing the infection. If no risk factors can be determined, empirical therapy should primarily cover gram-positive organisms. Generally, if streptococci are suspected, empirical treatment should consist of penicillin plus gentamicin. However, if staphylococci or enterococci are suspected, empirical treatment should consist ofvancomycin plus gentamicin. It is important to monitor the patient s response to therapy closely until cultures and susceptibilities are determined to ensure adequate treatment.

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