Genomics

^ Therapeutic response in AD is genotype-specific depending upon the genes associated with pathogenesis and/or genes responsible for drug metabolism. Recent investigations have demonstrated that the therapeutic response in AD is genotype-specific, depending upon genes associated with AD pathogenesis and/or genes responsible for drug metabolism. apo E-4/4 carriers tend to show a faster disease progression and a poorer therapeutic response to all available treatments than any other polymorphic variant associated with AD. Extensive and intermediate metabolizers of CYP450 enzymes are the best responders to pharmacotherapy, while poor and ultrarapid meta-bolizers are the worst responders. The pharmacogenetic response in AD may depend upon the interaction of genes involved in drug metabolism and the genes associated with AD pathogenesis.5

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