Glutamate is the primary excitatory neurotransmitter in the CNS involved in memory, learning, and neuronal plasticity. It acts by providing information from one brain area to another and affects cognition through facilitation of connections with cholinergic neurons in the cerebral cortex and basal forebrain.18 In AD, one type of glutamate receptor, #-methyl-D-aspartate (NMDA), is less prevalent than normal. There also appears to be overactivation of unregulated glutamate signaling. This results in a rise in calciumions that induces secondary cascades, which lead to neuronal death and an increased production of APP.17 The increased production of APP is associated with higher rates of plaque development and hyperphosphorylation of t protein.19 Memantine is a noncompetitive NMDA antagonist that targets this path-ophysiologic mechanism.20

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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