The hematogenous route occurs through the seeding of the urinary tract with pathogens carried by the blood supply. These pathogens represent an infection at some other primary site in the body. Staphylococcus aureus bacteremia, for example, can cause renal abscesses via the hematogenous route, and pyelonephritis can be experimentally produced by IV injection of Salmonella spp., Mycobacterium tuberculosis, or even yeast (Candida spp.) into rabbits.18 However, experimentally creating this pathway has not been successful with all organisms. Experimental hematogenous seeding of the kidneys could not be created with the IV injection of large innocula of E. coli or P aeruginosa in a mouse model.19
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