Hypercortisolism cushings syndrome epidemiology and etiology

Cushing's syndrome refers to the pathophysiologic changes associated with exposure to supraphysiologic cortisol concentrations (endogenous hypercortisolism) or pharma-cologic doses of glucocorticoids (exogenous hypercortisolism). Cushing's syndrome from endogenous causes is a rare condition, with an estimated incidence of two to five cases per 1 million persons per year.14 Patients receiving chronic supraphysiologic doses of glucocorticoids, such as those with rheumatologic disorders, are at high risk of developing Cushing's syndrome.

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