• May manifest as asymptomatic disease, acute diarrhea, or persistent diarrhea lasting for several weeks

• Usually self-limiting Immunocompromised

• May manifest as asymptomatic disease; transient infection for less than 2 months; chronic diarrhea lasting at least 2 months, or fulminant infection, with at least 2 L of watery stool per day

• Asymptomatic disease more common in those with a CD4+ cell count greater than

200 cells/mm , and fulminant infection more common in those with a CD4+ cell

count of less than 50 cells/mm

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