Immunosuppressive Therapies Treatment of Acute Rejection Episodes

Acute rejection is generally treated with a course of high-dose methylprednisolone (250-1,000 mg/day IV for 3 days), which is usually sufficient to ameliorate the rejection episode. If the acute rejection episode is resistant to the initial course of steroids, a second course may be administered or the patient may begin therapy with antithy-mocyte globulin (1.5 mg/kg/day for 3-14 days). Acute rejection refractory to these treatments may require OKT-3. However, the use of this agent has fallen out of favor due to the severe short- and long-term adverse events associated with its use.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

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