Insulin is one of a very few medications which is itself a whole protein, and can induce

IgE sensitivity directly. This can result in anaphylaxis. Adverse reactions to insulin

also include erythema, pruritis, and indurations, which are usually transient and may be injection site-related. For the sensitivity reactions, treatment options include dexa-methasone or desensitization. If the reaction is injection site-related, a change in delivery system (i.e., insulin pump or inhaled insulin) may be helpful.

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