Invasive Carcinoma

Invasive breast cancers are a histologically heterogeneous group of lesions. Most breast carcinomas are adenocarcinomas and are classified on the basis of their microscopic appearance as either ductal or lobular, corresponding to the ducts and lobules of the normal breast. The various histologic types of breast cancer have different prognoses, but it is unknown whether their response to therapy differs because patients in therapeutic trials typically are not stratified according to histologic type. Infiltrating lobular carcinoma commonly metastasizes to meningeal and serosal surfaces and other unusual sites, whereas other types usually metas-tasize to the bone, brain, or liver.

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