Key Concepts

Nausea and vomiting are symptoms that can be due to a number of different causes.

To treat nausea and vomiting most effectively, it is important to first identify the underlying cause of the symptoms.

Nonpharmacologic approaches to treating nausea and vomiting include dietary, physical, and psychological changes.

'O' For prevention of acute chemotherapy-induced nausea and vomiting (CINV) for patients receiving moderately or highly emetogenic chemotherapy, a combination of antiemetics with different mechanisms of action is recommended.

© Droperidol or a 5-hydroxytryptamine (serotonin) type 3 (5-HT3) receptor antagonist should be administered at the end of surgery to patients at high risk for developing postoperative nausea and vomiting (PONV).

Nausea and vomiting affect the majority of pregnant women; the teratogenic potential of the therapy is the primary consideration in drug selection.

Because the vestibular system is replete with muscarinic type cholinergic and histaminic (Hi) receptors, anticholinergics and antihistamines are the most commonly used pharmacologic agents to prevent and treat motion sickness.

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