Key Concepts

Inflammatory bowel disease (IBD) includes both ulcerative colitis (UC) and Crohn's disease (CD) and is associated with inflammation of various areas of the GI tract.

O1 Differentiation of UC and CD is based on signs and symptoms as well as characteristic endoscopic findings including the extent, pattern, and depth of inflammation.

Patients may manifest extraintestinal symptoms of IBD, such as arthritis, primary sclerosing cholangitis, erythema nodosum, and pyoderma gangrenosum, among others.

Û1 Major treatment goals for patients with IBD include alleviation of signs and symptoms and suppression of inflammation during acute episodes and maintenance of remission thereafter.

When designing a drug regimen for treatment of IBD, several factors should be considered, including the patient's symptoms, medical history, current medication use, drug allergies, and location and severity of disease.

® Antidiarrheal medications that reduce GI motility, such as loperamide, diphenoxylate/atropine, and codeine should be avoided in patients with active IBD due to the risk of precipitating acute colonic dilation (toxic megacolon).

^^ Treatment of acute episodes of UC is dictated by the severity and extent of disease, and first-line therapy of mild to moderate disease involves oral or topical aminosalicylate derivatives.

® Maintenance of remission of UC maybe achieved with oral or topical aminosalicylates. Immunosuppressants such as azathioprine, 6-mercaptopurine (6-MP), or infliximab can be used for unresponsive patients or those who develop corticost-eroid dependency.

Treatment of active mild to moderate CD involves use of oral or topical aminosalicylate derivatives, whereas moderate to severe disease may require systemic corticosteroid therapy.

© Maintenance of remission of CD maybe achieved with oral or topical aminosali-cylate derivatives, immunosuppressants (such as azathioprine, 6-MP, and metho-trexate), or infliximab, adalimumab, certolizumab, or natalizumab.

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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