Laboratory Tests

• The initial lab evaluation should include CBC with differential, coagulation studies, serum chemistries with renal and liver function, and urinalysis.

• Serum concentrations of D-dimer, a by-product of thrombin generation, will be elevated in an acute event. The patient may have an elevated erythrocyte sedimentation rate (ESR) and WBC.

• The D-dimer test cannot be used alone to prove the presence of a DVT because it can be elevated in many other conditions. A D-dimer level of less than 500 ng/mL (less than 500 mcg/L) with a low clinical probability of DVT is helpful and cost effective in excluding DVT without the need for ultrasound testing.

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