Macroin Jeazslicla

3r Clindamycin W- rifampin''

FIGURE 72-4. Treatment algorithm" for ABRS in patients with mild disease and recent antibiotic exposure or moderate disease. "Antimicrobials are listed in order of predicted efficacy based on predicted clinical and bacteriologic efficacy rates, clinical studies, safety, and tolerability. Doses can be found in Table 72-4.

Cephalosporins should be considered for patients with nontype I hypersens-

cRespiratory itivity to penicillins; they are more likely to be effective than the alternative agents. fluoroquinolone = levofloxacin, moxifloxacin. ^Combination therapy should provide gram-positive and gram-negative coverage. Examples are highdose amoxicillin or clindamycin plus rifampin or ce-fixime. There are no published clinical studies to support such combinations. (From Refs. 23, 24.)

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