Maintenance Immunosuppressive Therapies Common Drug Drug Interactions

As the number of medications that a patient takes increases, so does the potential for DDIs. Disease severity, patient age, and organ dysfunction are all risk factors for increased DDIs. In general, DDIs can be broken down into two categories: (a) pharmacokinetic interactions, and (b) pharmacodynamic interactions.

• Pharmacokinetic interactions result when one drug alters the absorption, distribution, metabolism, or elimination of another drug.

• Pharmacodynamic interactions include additive, synergistic, or antagonistic interactions that can affect efficacy or toxicity.

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