Manganese Toxicity

Manganese is a trace element that serves as a coenzyme in multiple biochemical reactions. Manganese usually is supplied in PN admixtures as part of the trace element package in an adult dose of 0.5 mg/day; however, this may be excessive for longer-term PN patients. Manganese accumulation can occur in patients with cholestasis, and the most common toxicity is neurotoxicity, but liver toxicity also may occur. Neurologic symptoms associated with manganese toxicity include headache, somnolence, weakness, confusion, tremor, muscle rigidity, altered gait, and mask-like face

(a Parkinson's-like syndrome). Conversely, some patients with hypermanganesemia may not exhibit symptoms of toxicity. Periodic measurement of blood-manganese concentrations in patients on long-term PN is recommended. Patients with cholestasis receiving PN may require restriction of manganese in PN to prevent its accumulation and possible toxicity.

Naturally Cure Your Headaches

Naturally Cure Your Headaches

Are Headaches Taking Your Life Hostage and Preventing You From Living to Your Fullest Potential? Are you tired of being given the run around by doctors who tell you that your headaches or migraines are psychological or that they have no cause that can be treated? Are you sick of calling in sick because you woke up with a headache so bad that you can barely think or see straight?

Get My Free Ebook


Post a comment