Mechanisms of Acute Rejection

After activation, cytotoxic T cells emerge from lymphoid organs to infiltrate the graft and trigger the immune response. These cells have been shown to induce graft destruction via two mechanisms: (a) secretion of the cytotoxic proteins perforin and gran-zyme B and (b) induction of cellular apoptosis through interaction with various cell surface receptors. Besides the cytotoxic T cells, several other cell lines may play a role in allograft destruction including B cells, granulocytes, and natural killer cells.

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