Mechanisms of Acute Rejection

After activation, cytotoxic T cells emerge from lymphoid organs to infiltrate the graft and trigger the immune response. These cells have been shown to induce graft destruction via two mechanisms: (a) secretion of the cytotoxic proteins perforin and gran-zyme B and (b) induction of cellular apoptosis through interaction with various cell surface receptors. Besides the cytotoxic T cells, several other cell lines may play a role in allograft destruction including B cells, granulocytes, and natural killer cells.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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