Meningococcal Vaccines

Neisseria meningitidis is a significant cause of meningitis and severe sepsis. Meningococcus causes an estimated 2,500 cases of invasive disease each year in the United States. Invasive meningococcal disease is associated with an estimated 15% mortality rate. Morbidity in survivors is substantial, with approximately 20% having loss of limb or neurologic sequelae. The highest rates of meningococcal disease are among young children; however, rates have been increasing in adolescents and young adults. Thirteen meningococcal serogroups have been identified; however, five serogroups, A, B, C, Y, and W-135, are responsible for epidemic and endemic disease worldwide. Despite the availability of highly active antibacterial agents against N meningitidis, there has been little impact on decreasing the morbidity and mortality due to invasive meningococcal disease.12

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

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