MTOR Inhibitors

The mammalian target of rapamycin (mTOR) is a downstream mediator in the phos-phatidylinositol 3-kinase/Akt signaling pathway which controls translation of proteins that regulate cell growth and proliferation, but also angiogenesis and cell survival.


The mTOR is an intracellular component which stimulates protein synthesis by phos-phorylating translation regulators, and contributes to protein degradation and an-giogenesis. Temsirolimus is approved for the treatment advanced renal cell carcinoma. The pharmacokinetics of temsirolimus are best described by a two-compartment mod el, with a terminal half-life of 13 to 25 hours. Elimination is primarily via the feces. Temsirolimus, and its metabolite sirolimus, are substrates of the cytochrome P4503A4/5 isoenzyme system. The primary side effects of temsirolimus include mucositis, diarrhea, maculopapular rash, nausea, leucopenia, thrombocytopenia, and hy-perglycemia.

Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook

Post a comment