Neuropeptides

Several neuropeptides are under investigation for their role in anxiety disorders. Important neuropeptides include neuropeptide Y (NPY), substance P, and cholecys-tokinin. NPY appears to reduce the effect of stress hormones and inhibits activity of the LC. Both mechanisms may contribute to the anxiolytic properties seen experimentally. Substance P may have anxiolytic and antidepressant properties due in part

to its effects on corticotropin-releasing hormone.

generalized anxiety disorder

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