Nonpharmacologic Therapy

Interpersonal therapy and cognitive behavioral therapy are psychotherapies that have well-documented efficacy for the treatment of MDD. Psychotherapy alone is an initial treatment option for mild-to-moderate depression, and it may be useful when combined with pharmacotherapy in the treatment of more severe cases. The combination of psychotherapy and pharmacotherapy can be more effective than either treatment modality alone in severe or recurrent MDD. It may be especially helpful for patients with significant6)sychosocial stressors, interpersonal difficulties, or comorbid personality disorders.1

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